What you can do for your health which boost your immunity

What you can do for your health which boost your immunity - AZSP Healing

Among recent several pandemics and there could be more diseases follow, the very fundamental things what we can do is maintain and improve immunity. We know that would be not easy to do something like to be accomplished at once. But, we can keep trying to improve our health. It would not be too late, not difficult to do. Those would be things, that just you can try them, if you want to keep your health and better life. Here's the information how we can maintain and improve our immunity.

What is immune system ?

There are a lot of things around us, such as bacteria, viruses, dust and pollutants. When you don't get sick even if you are surrounded by such substances, it is because of the immune system, which protect against those and eliminates those substances from your body. The immune function is the power to maintain the body younger and healthy. However, if you get too stressed or your lifestyle is disturbed, it won't be able to function properly. The key for the immune system to be properly functional is whether the autonomic nervous system works with balanced in the homeostasis or not. Autonomic nerves have sympathetic and parasympathetic nerves. Sympathetic nerves have more supremacy or dominant when they are active during the day. It is a nerve that enhances the activity of the whole body, and it works to raise blood pressure and blood sugar, and collect blood into muscles and brain. Parasympathetic nerves mainly work at night when they are relaxed. It is a nerve that restores the body, and it has the effect of enhancing the function of the internal organs and normalizing immune sytem functionality. There is an image that "stress is bad", but it will be sharper in your life if there is a little more than a state where there is no stress at all, and it will be easier to proceed with work and study. However, if you are exposed to strong stress over a long period of time, the function of the autonomic nervous system could be disturbed, and only the sympathetic nerves would be always assertive. If that happens, the immune function would not work properly. So, what kind of things we can do to balance the autonomic nervous system in order to maintain immune system functional for optimal health ?

The function of the autonomic nervous system is greatly influenced by the mental health. So we can say that dealing with stress is very important point. And of course, it might be also necessary to look your lifestyle over again.

1. Exercises

First, you may only need to do about 20 minutes of exercises a day at least, so it is important to make it as a daily routine. It would be good to be able to take a walk with a little sweat. If you are so exhausted from the exercisess, it could be too much. Please stay in optimal level of exercises unless if you are athletes. In addition to improving immune function, exercise has effects such as preventing lifestyle-related issues, preventing falls, and activating the brain.

2. Good Sleep

If you sleep well at night, you will be able to get up, move and work with higher performance during the day. It is also important to ensure the rhythm of sleep in order to make a natural turn over between activate sympathetic nerves during the day and parasympathetic nerves functional well at night. * For more information including nutritional recommendation for good sleep, please refer to the ariticle "Healthy Good Sleep" from AZ Sportivo Performance. Shop - Essential Oils for Sleep Shop - Tea for Sleep

3. Stress Management

People who are busy at work and always come home late would not have enough relaxation time. In addition, busyness is easy to cause drinking too much and overeating from stress. Finishing work earlier, go home earlier, if possible. And take a time for relaxation. People who has strong sense of responsibility are often forced themselves to work too hard. It may also be necessary to "Take it easy and relaxed" somehow. Even just a take deep breath, 10 minutes tea time would help you as well. Also, Meditation, mindfulness, Yoga, Zen, Qigong would help for you stress management. * For more information about Qigong, please refer Qigong Healing Exercise provided by AZSP Healing ** For service information regarding Energy Healing which include Stress Relieaf, please refer AZSP Energy Healing provided by AZSP Healing Shop - Tea for Relaxation

4. Keep your body warm

When basal body temperature is higher, the lymphocytes increased and activated, and the immunity boosted up. Also, when the body warms up, the blood vessels dilate and the parasympathetic nerves can be more assertive, making it easier to relax. It's a good idea to take a bath at about 40 degC(or about 104 degF) for more than 10 minutes. Only shower alone would not warm your body and stimulates your sympathetic nerves, so you can't relax much. Try to take a bath slowly with lukewarm water. * For more information, please refer the article Salt Soaking Hot bathing - AZ Sportivo Performance Shop - Tea for keep your body warm

5. Power of laughing

When you laugh, parasympathetic nerves become more assertive. It is also known that NK cells, cells that control immunity, are activated. Even if you make a fake laugh, you would be in the state which those effect observed. Contracting the muscles for making smile, zygomatics major, depressor anguli oris, zygomatics minor, levator labii superioris, risorius would make parasympathetic nerves more assertive.

6. Foods for immunity

There are also foods that warm your body, Yang foods in Chinese Traditional Medicine. It is said that edible plants that been burried in the soil, such as root vegetables, potatoes, and ginger, have the effect of increase and maintain the basal body temperature which improve immunity.

Garlic

Garlic has lots of health benefits. One of phytochemical compound, allicin found in garlic is the source of the strong smell and its flavor, although its efficacy for health is not only enhance immunity, but also antimicrobial, improve metabolism, weight loss, improve cognitive function and even reduce risk of certain types of cancer. Research studies show more effectiveness of Garlic which includes reduce blood pressure, lower LDL-cholesterol, improve HDL-cholesterol and reduce risk of heart disease as well.

Ginger

Ginger has been popular for a long time as an ingredient that has a highly effectiveness for health and its flavor. Ginger roots boost Yang Qi which has been told in Traditional Chinese Medicine, warm your body. What we can expect as health effectivness of ginger are from the three major ingredients of ginger, which are Gingerol, Shogaol and Zingerone, in addtion to them, there are plenty of vitamins minerals and dietary fibers. The most signaficant health benefit from ginger would be antioxidants and anti-inflammation which would help for one of root cause for many diseases and symptoms, reduce inflammation from whole body. And other health benefit would be reduce blood sugar levels, stomach/digestive issue improvement, weight loss, lower cholesterol levels, improve brain function and pain relief.   According to a research study about the pain relief or analgesic effect of ginger, the most effective was the relief of menstrual pain. It was also found that drinking ginger tea during menstruation can reduce nausea. However, there is also a regrettable research study that if you usually take acetaminophen or ibuprofen as painkillers, you would not get that efficacy well. On the contrary, ginger may affect the effect of the medicine, so if you are undergoing medication such as illness, be sure to consult your doctor before you start taking ginger extract or tablets.

Red Cabbage

Red Cabbage is very rich in Anthocyanin and Vitamin C. Anthocyanin is phytochemical flavonoid pigment very effective antioxidant. Vitamin C is a nutrient that plays various roles in human body, such as promoting iron absorption, strengthening immunity, activating enzymes that metabolize toxic substances that have entered into the body, and prevention of heart disease due to antioxidant action. In immune system, Vitamin C is contained a lot in white blood cells and lymphocytes that fight against viruses and bacteria in the human body, so taking vitamin C strengthens immune function and increases resistance to diseases. In addition, the reactive oxygen species would be generated when white blood cells fight against viruses and bacteria attacks normal cells if they occur excessively, but the antioxidant action of vitamin C suppresses the function of reactive oxygen species. Vitamin C is consumed rapidly by stress. If you are in condition under anxiety, fatigue, heat, cold, lack of sleep, or a cold, please take vitamin C more. Vitamin C is also indispensable for the production of adrenaline against stress, so it is effective to increase stress resistance as well. Other Vitamin C rich foods are Bell peppers, Broccoli, Kiwi fruits, strawberry, Kale, Spinach, Brussel Sprouts, Papaya, grapefruits, orage, tangerine, Lemmon, Lime, etc.

Spinach

Spinach is rich in various nutrients including vitamin C, vitamin K, folic acid, iron, calcium, lutein, Beta-carotene, kaenpferol, nitric acid. As described in the Red Cabbage, we don't repeat Vitamin C explanation regarding improving immunity here. But, mention about the very important efficacy of Spinach, which would be help bulding blood cells and its purification. The iron contained in spinach is a component of hemoglobin that transports oxygen in the blood to the whole body, and it would help for anemia, muscle fatigue, headache and shortness of breath if the symptoms are from insufficient of iron. Iron absorption is increased by vitamin C and Folic acid, as well. So, there are very effective ingredients to building blood cells in spinach. Although, one of the phytochemical in spinach, which could make worse the absorption of iron and calcium, is oxalates. So, you would better to process, boiling and putting it to water before eat. But, if you dip it in water long time, vitamin C will be flowed out, so you may need to minimize the process. Most of carbogydrate in spinach exisists as dietary fibers, which would be good prebiotics and help intestinal health as well.

Broccoli

Broccoli contains vitamin C, which would improve immunity, as well as Red Cabbage and Spinach, and also contains Vitamin A, Vitamin E, minerals, dietary fibers, Sulphoraphane. Vitamin E promotes blood circulation. Vitamin E also increases the antioxidant effect by taking it together with vitamin C, which would suppress reactive oxygen species, which also leads to strengthening basic resistance. Sulforaphane would inhibits the growth of cancer cells. The amount of sulforaphane in raw broccoli is about three times greater than cooked broccoli. Sulforaphane has the ability to induce expression of sevral enzymes via the KEAP1/Nrf2 pathways typically characterized as Phase II detoxification enzymes, which are crucial to remove mercury and carcinogens. Most of Dietary fibers in broccoli is insoluble, which reach intestent and become prebiotics, would help intestival health.

Mushrooms

Mushrooms are very low calorie in diet, contains dietary fibers, vitamins, minerals and also one of polysaccharides, Beta-Glucan. Vitamin B1 works on the metabolism of glucoses and carbohydrates. If you are lack of vitamin B1, your body would has difficulty to turn glucoses and carbohydrates into energy, so the excess glucoses and carbohydrates would be accumulated as fat in your body and cause obesity. In addition, vitamin B1 would improve stamina, concentration, and reduce fatigue as well. Vitamin B2 is a component related to the metabolism of lipids and works to keep and maintain the skin and mucous membranes. If you are insufficient in vitamin B2, it could cause stomatitis and dermatitis. Mucous membrane immunity in mucous membranes such as mouths that become the invasion ports of the virus. Mucous membrane immunity prevents viruses from entering into the body, so if the mucous membrane is not kept healthy due to the lack of vitamin B2, the immunity could decrease. Vitamin B6 is used in various enzyme reactions in human body related to metabolism. If vitamin B6 is insufficient, the metabolism would be worse and as a result, the body would be difficult to keep body temperature, it would be hard to increase temperature. In the state of hypothermia, the flow of blood would become worse and which lowers immunity. Vitamin D is the nutrition that promotes the absorption of calcium and can be synthesized in the body by sunbathing. If you try to take vitamin D from food, you can only take it from limited foods such as mushrooms and fish. By promoting the absorption of calcium, it creates strong bones and also acts on muscle development. When muscles develop, it not only increases immunity, but also leads to prevention of osteoporosis and diabetes. Beta-glucan, which is most likely contained in mushroom cell walls, is very effective for increasing immunity. Beta-glucan activates the function of natural killer cells and white blood cells in the immune system. Therefore, in addition to preventing colds, it would prevent and improve allergies, even it would prevent cancer as well. In addition, beta-glucan is also effective for helping intestinal environment, so the people who are suffering from constipation may be able to expect improvement of the symptoms. Other foods source of Beta-glucan would be oats, barley, seaweeds etc. * For more information about intestinal health, please refer the article Types and effects of lactic acid bacteria ** For service information including foods for immunity, please refer Food Healing Science prvided by AZSP Healing

epilogue

There is a study that people with good lifestyles has longevity, live longer. People who have many good habits such as "not smoking", "drinking moderately" or "not drinking at all", "exercise regularly", "maintaining a proper weight", "sleeping 7 to 8 hours", "eating breakfast," would have higher physical and mental health. In addition, it is known that people who have acquired good habits since they are young are healthy, but they also have health benefits even if they improve their lifestyle habits after they get older. If younger, you would be able to improve your lifestyle better, but it's not too late even when you get older.



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References 1: Simpson RJ, Campbell JP, Gleeson M, Krüger K, Nieman DC, Pyne DB, Turner JE, Walsh NP. Can exercise affect immune function to increase susceptibility to infection? Exerc Immunol Rev. 2020;26:8-22. PMID: 32139352. 2: Nieman DC, Pence BD. Exercise immunology: Future directions. J Sport Health Sci. 2020 Sep;9(5):432-445. doi: 10.1016/j.jshs.2019.12.003. Epub 2019 Dec 30. PMID: 32928447; PMCID: PMC7498623. 3: Wang J, Liu S, Li G, Xiao J. Exercise Regulates the Immune System. Adv Exp Med Biol. 2020;1228:395-408. doi: 10.1007/978-981-15-1792-1_27. PMID: 32342473. 4: Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the Regulation of Immune Functions. Prog Mol Biol Transl Sci. 2015;135:355-80. doi: 10.1016/bs.pmbts.2015.08.001. Epub 2015 Sep 5. PMID: 26477922. 5: Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev. 2000 Jul;80(3):1055-81. doi: 10.1152/physrev.2000.80.3.1055. PMID: 10893431. 6: Besedovsky L, Lange T, Haack M. The Sleep-Immune Crosstalk in Health and Disease. Physiol Rev. 2019 Jul 1;99(3):1325-1380. doi: 10.1152/physrev.00010.2018. PMID: 30920354; PMCID: PMC6689741. 7: Irwin MR, Opp MR. Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity. Neuropsychopharmacology. 2017 Jan;42(1):129-155. doi: 10.1038/npp.2016.148. Epub 2016 Aug 11. PMID: 27510422; PMCID: PMC5143488. 8: Poluektov MG. Son i immunitet [Sleep and immunity]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(9. Vyp. 2):6-12. Russian. doi: 10.17116/jnevro20201200926. PMID: 33076639. 9: Besedovsky L, Lange T, Born J. Sleep and immune function. Pflugers Arch. 2012 Jan;463(1):121-37. doi: 10.1007/s00424-011-1044-0. Epub 2011 Nov 10. PMID: 22071480; PMCID: PMC3256323. 10: Appenheimer MM, Evans SS. Temperature and adaptive immunity. Handb Clin Neurol. 2018;156:397-415. doi: 10.1016/B978-0-444-63912-7.00024-2. PMID: 30454603. 11: Wang X, Ni L, Wan S, Zhao X, Ding X, Dejean A, Dong C. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Immunity. 2020 Feb 18;52(2):328-341.e5. doi: 10.1016/j.immuni.2020.01.006. Epub 2020 Feb 11. PMID: 32049050. 12: Yim J. Therapeutic Benefits of Laughter in Mental Health: A Theoretical Review. Tohoku J Exp Med. 2016 Jul;239(3):243-9. doi: 10.1620/tjem.239.243. PMID: 27439375. 13: Pressman SD, Acevedo AM, Hammond KV, Kraft-Feil TL. Smile (or grimace) through the pain? The effects of experimentally manipulated facial expressions on needle-injection responses. Emotion. 2021 Sep;21(6):1188-1203. doi: 10.1037/emo0000913. Epub 2020 Nov 23. PMID: 34881943. 14: Hassed C. How humour keeps you well. Aust Fam Physician. 2001 Jan;30(1):25-8. PMID: 11211708. 15: Christie W, Moore C. The impact of humor on patients with cancer. Clin J Oncol Nurs. 2005 Apr;9(2):211-8. doi: 10.1188/05.CJON.211-218. PMID: 15853164. 16: Fonzi L, Matteucci G, Bersani G. Riso e depressione: ipotesi di rapporto patogenetico e terapeutico [Laughter and depression: hypothesis of pathogenic and therapeutic correlation]. Riv Psichiatr. 2010 Jan-Feb;45(1):1-6. Italian. PMID: 20380236. 17: Seaward BL. Humor's healing potential. Health Prog. 1992 Apr;73(3):66-70. PMID: 10116744. 18: Wilkins J, Eisenbraun AJ. Humor theories and the physiological benefits of laughter. Holist Nurs Pract. 2009 Nov-Dec;23(6):349-54. doi: 10.1097/HNP.0b013e3181bf37ad. PMID: 19901609. 19: Varshney R, Budoff MJ. Garlic and Heart Disease. J Nutr. 2016 Feb;146(2):416S-421S. doi: 10.3945/jn.114.202333. Epub 2016 Jan 13. PMID: 26764327. 20: Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect. 1999 Feb;1(2):125-9. doi: 10.1016/s1286-4579(99)80003-3. PMID: 10594976. 21: Nicastro HL, Ross SA, Milner JA. Garlic and onions: their cancer prevention properties. Cancer Prev Res (Phila). 2015 Mar;8(3):181-9. doi: 10.1158/1940-6207.CAPR-14-0172. Epub 2015 Jan 13. PMID: 25586902; PMCID: PMC4366009. 22: Zhang Y, Liu X, Ruan J, Zhuang X, Zhang X, Li Z. Phytochemicals of garlic: Promising candidates for cancer therapy. Biomed Pharmacother. 2020 Mar;123:109730. doi: 10.1016/j.biopha.2019.109730. Epub 2019 Dec 23. PMID: 31877551. 23: Ried K. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review. J Nutr. 2016 Feb;146(2):389S-396S. doi: 10.3945/jn.114.202192. Epub 2016 Jan 13. PMID: 26764326. 24: Sun YE, Wang W, Qin J. Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis. Medicine (Baltimore). 2018 May;97(18):e0255. doi: 10.1097/MD.0000000000010255. PMID: 29718835; PMCID: PMC6392629. 25: Sultan MT, Butt MS, Qayyum MM, Suleria HA. Immunity: plants as effective mediators. Crit Rev Food Sci Nutr. 2014;54(10):1298-308. doi: 10.1080/10408398.2011.633249. PMID: 24564587. 26: Xiong XJ, Wang PQ, Li SJ, Li XK, Zhang YQ, Wang J. Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials. Phytomedicine. 2015 Mar 15;22(3):352-61. doi: 10.1016/j.phymed.2014.12.013. Epub 2015 Feb 4. PMID: 25837272. 27: Xu C, Mathews AE, Rodrigues C, Eudy BJ, Rowe CA, O'Donoughue A, Percival SS. Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr ESPEN. 2018 Apr;24:148-155. doi: 10.1016/j.clnesp.2017.11.010. Epub 2018 Jan 3. PMID: 29576354. 28: Wlosinska M, Nilsson AC, Hlebowicz J, Hauggaard A, Kjellin M, Fakhro M, Lindstedt S. The effect of aged garlic extract on the atherosclerotic process - a randomized double-blind placebo-controlled trial. BMC Complement Med Ther. 2020 Apr 29;20(1):132. doi: 10.1186/s12906-020-02932-5. PMID: 32349742; PMCID: PMC7191741. 29: Choudhary PR, Jani RD, Sharma MS. Effect of Raw Crushed Garlic (Allium sativum L.) on Components of Metabolic Syndrome. J Diet Suppl. 2018 Jul 4;15(4):499-506. doi: 10.1080/19390211.2017.1358233. Epub 2017 Sep 28. PMID: 28956671. 30: Shukla Y, Kalra N. Cancer chemoprevention with garlic and its constituents. Cancer Lett. 2007 Mar 18;247(2):167-81. doi: 10.1016/j.canlet.2006.05.009. Epub 2006 Jun 21. PMID: 16793203. 31: De Greef D, Barton EM, Sandberg EN, Croley CR, Pumarol J, Wong TL, Das N, Bishayee A. Anticancer potential of garlic and its bioactive constituents: A systematic and comprehensive review. Semin Cancer Biol. 2021 Aug;73:219-264. doi: 10.1016/j.semcancer.2020.11.020. Epub 2020 Dec 7. PMID: 33301861. 32: Gorinstein S, Jastrzebski Z, Namiesnik J, Leontowicz H, Leontowicz M, Trakhtenberg S. The atherosclerotic heart disease and protecting properties of garlic: contemporary data. Mol Nutr Food Res. 2007 Nov;51(11):1365-81. doi: 10.1002/mnfr.200700064. PMID: 17966138. 33: Rana SV, Pal R, Vaiphei K, Sharma SK, Ola RP. Garlic in health and disease. Nutr Res Rev. 2011 Jun;24(1):60-71. doi: 10.1017/S0954422410000338. PMID: 24725925. 34: Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2008 Jun 16;8:13. doi: 10.1186/1471-2261-8-13. PMID: 18554422; PMCID: PMC2442048. 35: Farhat Z, Hershberger PA, Freudenheim JL, Mammen MJ, Hageman Blair R, Aga DS, Mu L. Types of garlic and their anticancer and antioxidant activity: a review of the epidemiologic and experimental evidence. Eur J Nutr. 2021 Oct;60(7):3585-3609. doi: 10.1007/s00394-021-02482-7. Epub 2021 Feb 4. PMID: 33543365. 36: Borek C. Garlic reduces dementia and heart-disease risk. J Nutr. 2006 Mar;136(3 Suppl):810S-812S. doi: 10.1093/jn/136.3.810S. PMID: 16484570. 37: Tattelman E. Health effects of garlic. Am Fam Physician. 2005 Jul 1;72(1):103-6. PMID: 16035690. 38: Petropoulos S, Fernandes Â, Barros L, Ciric A, Sokovic M, Ferreira ICFR. Antimicrobial and antioxidant properties of various Greek garlic genotypes. Food Chem. 2018 Apr 15;245:7-12. doi: 10.1016/j.foodchem.2017.10.078. Epub 2017 Oct 16. PMID: 29287429. 39: Mofrad MD, Rahmani J, Varkaneh HK, Teymouri A, Mousavi SM. The effects of garlic supplementation on weight loss: A systematic review and meta-analysis of randomized controlled trials. Int J Vitam Nutr Res. 2021 Jun;91(3-4):370-382. doi: 10.1024/0300-9831/a000607. Epub 2019 Jul 30. PMID: 31357923. 40: Zadhoush R, Alavi-Naeini A, Feizi A, Naghshineh E, Ghazvini MR. The effect of garlic (Allium sativum) supplementation on the lipid parameters and blood pressure levels in women with polycystic ovary syndrome: A randomized controlled trial. Phytother Res. 2021 Nov;35(11):6335-6342. doi: 10.1002/ptr.7282. Epub 2021 Sep 8. PMID: 34496450. 41: Myneni AA, Chang SC, Niu R, Liu L, Swanson MK, Li J, Su J, Giovino GA, Yu S, Zhang ZF, Mu L. Raw Garlic Consumption and Lung Cancer in a Chinese Population. Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):624-33. doi: 10.1158/1055-9965.EPI-15-0760. Epub 2016 Jan 25. PMID: 26809277; PMCID: PMC4873399. 42: Yeh YY, Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr. 2001 Mar;131(3s):989S-93S. doi: 10.1093/jn/131.3.989S. PMID: 11238803. 43: Kim JY, Kwon O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims. Am J Clin Nutr. 2009 Jan;89(1):257-64. doi: 10.3945/ajcn.2008.26142. Epub 2008 Dec 3. PMID: 19056580. 44: Goncagul G, Ayaz E. Antimicrobial effect of garlic (Allium sativum). Recent Pat Antiinfect Drug Discov. 2010 Jan;5(1):91-3. doi: 10.2174/157489110790112536. PMID: 19929845. 45: Ali M, Thomson M, Afzal M. Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance. Prostaglandins Leukot Essent Fatty Acids. 2000 Feb;62(2):55-73. doi: 10.1054/plef.1999.0124. PMID: 10780871. 46: Reinhart KM, Coleman CI, Teevan C, Vachhani P, White CM. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta- analysis. Ann Pharmacother. 2008 Dec;42(12):1766-71. doi: 10.1345/aph.1L319. Epub 2008 Nov 18. PMID: 19017826. 47: Khanum F, Anilakumar KR, Viswanathan KR. Anticarcinogenic properties of garlic: a review. Crit Rev Food Sci Nutr. 2004;44(6):479-88. doi: 10.1080/10408690490886700. PMID: 15615431. 48: Lamm DL, Riggs DR. Enhanced immunocompetence by garlic: role in bladder cancer and other malignancies. J Nutr. 2001 Mar;131(3s):1067S-70S. doi: 10.1093/jn/131.3.1067S. PMID: 11238818. 49: Rohner A, Ried K, Sobenin IA, Bucher HC, Nordmann AJ. A systematic review and metaanalysis on the effects of garlic preparations on blood pressure in individuals with hypertension. Am J Hypertens. 2015 Mar;28(3):414-23. doi: 10.1093/ajh/hpu165. Epub 2014 Sep 18. PMID: 25239480. 50: Talib WH. Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation. Nutrition. 2017 Nov-Dec;43-44:89-97. doi: 10.1016/j.nut.2017.06.015. Epub 2017 Jul 6. PMID: 28935151. 51: Wang HP, Yang J, Qin LQ, Yang XJ. Effect of garlic on blood pressure: a meta-analysis. J Clin Hypertens (Greenwich). 2015 Mar;17(3):223-31. doi: 10.1111/jch.12473. Epub 2015 Jan 5. PMID: 25557383; PMCID: PMC8031974. 52: Hosseini M, Shafiee SM, Baluchnejadmojarad T. Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin- diabetic rats. Pathophysiology. 2007 Oct;14(2):109-12. doi: 10.1016/j.pathophys.2007.07.002. Epub 2007 Sep 17. PMID: 17875387. 53: Castro C, Lorenzo AG, González A, Cruzado M. Garlic components inhibit angiotensin II-induced cell-cycle progression and migration: Involvement of cell-cycle inhibitor p27(Kip1) and mitogen-activated protein kinase. Mol Nutr Food Res. 2010 Jun;54(6):781-7. doi: 10.1002/mnfr.200900108. PMID: 19904760. 54: Mukherjee S, Lekli I, Goswami S, Das DK. Freshly crushed garlic is a superior cardioprotective agent than processed garlic. J Agric Food Chem. 2009 Aug 12;57(15):7137-44. doi: 10.1021/jf901301w. Retraction in: J Agric Food Chem. 2012 Mar 14;60(10):2766. PMID: 19722587; PMCID: PMC2775434. 55: Si W, Chen YP, Zhang J, Chen ZY, Chung HY. Antioxidant activities of ginger extract and its constituents toward lipids. Food Chem. 2018 Jan 15;239:1117-1125. doi: 10.1016/j.foodchem.2017.07.055. Epub 2017 Jul 12. PMID: 28873530. 56: An S, Liu G, Guo X, An Y, Wang R. Ginger extract enhances antioxidant ability and immunity of layers. Anim Nutr. 2019 Dec;5(4):407-409. doi: 10.1016/j.aninu.2019.05.003. Epub 2019 Jun 13. PMID: 31890918; PMCID: PMC6920395. 57: Kulkarni RA, Deshpande AR. Anti-inflammatory and antioxidant effect of ginger in tuberculosis. J Complement Integr Med. 2016 Jun 1;13(2):201-6. doi: 10.1515/jcim-2015-0032. PMID: 27089418. 58: Fahmi A, Hassanen N, Abdur-Rahman M, Shams-Eldin E. Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats. Biomarkers. 2019 Jul;24(5):436-447. doi: 10.1080/1354750X.2019.1606280. Epub 2019 May 7. PMID: 30979347. 59: Im JA, Kim MS, Kwon O, Shin JH, Kim JY. Animal model of intestinal anti- inflammatory effect of ginger-cinnamon complex. Food Sci Biotechnol. 2021 Sep 2;30(9):1249-1256. doi: 10.1007/s10068-021-00965-1. PMID: 34603823; PMCID: PMC8423877. 60: Abd El Hady Mousa M, Mansour H, Eid F, Mashaal A. Anti-inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamate. J Food Biochem. 2021 Jun 22:e13819. doi: 10.1111/jfbc.13819. Epub ahead of print. PMID: 34159624. 61: Jafarzadeh A, Nemati M. Therapeutic potentials of ginger for treatment of Multiple sclerosis: A review with emphasis on its immunomodulatory, anti- inflammatory and anti-oxidative properties. J Neuroimmunol. 2018 Nov 15;324:54-75. doi: 10.1016/j.jneuroim.2018.09.003. Epub 2018 Sep 12. PMID: 30243185. 62: Jeena K, Liju VB, Kuttan R. Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. Indian J Physiol Pharmacol. 2013 Jan-Mar;57(1):51-62. PMID: 24020099. 63: Ozkur M, Benlier N, Takan I, Vasileiou C, Georgakilas AG, Pavlopoulou A, Cetin Z, Saygili EI. Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties. Oxid Med Cell Longev. 2022 May 9;2022:4748447. doi: 10.1155/2022/4748447. PMID: 35585878; PMCID: PMC9110206. 64: Ezzat SM, Ezzat MI, Okba MM, Menze ET, Abdel-Naim AB. The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti- inflammatory activity. J Ethnopharmacol. 2018 Mar 25;214:113-123. doi: 10.1016/j.jep.2017.12.019. Epub 2017 Dec 16. PMID: 29253614. 65: Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti- oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J Prev Med. 2013 Apr;4(Suppl 1):S36-42. PMID: 23717767; PMCID: PMC3665023. 66: Adib Rad H, Basirat Z, Bakouei F, Moghadamnia AA, Khafri S, Farhadi Kotenaei Z, Nikpour M, Kazemi S. Effect of Ginger and Novafen on menstrual pain: A cross- over trial. Taiwan J Obstet Gynecol. 2018 Dec;57(6):806-809. doi: 10.1016/j.tjog.2018.10.006. PMID: 30545531. 67: Maharlouei N, Tabrizi R, Lankarani KB, Rezaianzadeh A, Akbari M, Kolahdooz F, Rahimi M, Keneshlou F, Asemi Z. The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(11):1753-1766. doi: 10.1080/10408398.2018.1427044. Epub 2018 Feb 2. PMID: 29393665. 68: Huang FY, Deng T, Meng LX, Ma XL. Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Medicine (Baltimore). 2019 Mar;98(13):e15054. doi: 10.1097/MD.0000000000015054. PMID: 30921234; PMCID: PMC6455977. 69: Taghizadeh M, Farzin N, Taheri S, Mahlouji M, Akbari H, Karamali F, Asemi Z. The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Ann Nutr Metab. 2017;70(4):277-285. doi: 10.1159/000471889. Epub 2017 Jun 9. PMID: 28595182. 70: Abdulrazak A, Tanko Y, Mohammed A, Mohammed KA, Sada NM, Dikko AA. Effects of Clove and Fermented Ginger on Blood Glucose, Leptin, Insulin and Insulin Receptor Levels in High Fat DietInduced Type 2 Diabetic Rabbits. Niger J Physiol Sci. 2018 Jun 30;33(1):89-93. PMID: 30091738. 71: Wilson PB. Ginger (Zingiber officinale) as an Analgesic and Ergogenic Aid in Sport: A Systemic Review. J Strength Cond Res. 2015 Oct;29(10):2980-95. doi: 10.1519/JSC.0000000000001098. PMID: 26200194. 72: Hajimoosayi F, Jahanian Sadatmahalleh S, Kazemnejad A, Pirjani R. Effect of ginger on the blood glucose level of women with gestational diabetes mellitus (GDM) with impaired glucose tolerance test (GTT): a randomized double-blind placebo-controlled trial. BMC Complement Med Ther. 2020 Apr 19;20(1):116. doi: 10.1186/s12906-020-02908-5. PMID: 32306991; PMCID: PMC7168816. 73: Wang D, Hiebl V, Ladurner A, Latkolik SL, Bucar F, Heiß EH, Dirsch VM, Atanasov AG. 6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Mol Nutr Food Res. 2018 May 26;62(14):e1800011. doi: 10.1002/mnfr.201800011. Epub ahead of print. PMID: 29802792; PMCID: PMC6099374. 74: Makhdoomi Arzati M, Mohammadzadeh Honarvar N, Saedisomeolia A, Anvari S, Effatpanah M, Makhdoomi Arzati R, Yekaninejad MS, Hashemi R, Djalali M. The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients with Type 2 Diabetes. Int J Endocrinol Metab. 2017 Aug 27;15(4):e57927. doi: 10.5812/ijem.57927. PMID: 29344037; PMCID: PMC5750786. 75: Shirvani MA, Motahari-Tabari N, Alipour A. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet. 2015 Jun;291(6):1277-81. doi: 10.1007/s00404-014-3548-2. Epub 2014 Nov 16. PMID: 25399316. 76: Barbalata T, Deleanu M, Carnuta MG, Niculescu LS, Raileanu M, Sima AV, Stancu CS. Hyperlipidemia Determines Dysfunctional HDL Production and Impedes Cholesterol Efflux in the Small Intestine: Alleviation by Ginger Extract. Mol Nutr Food Res. 2019 Oct;63(19):e1900029. doi: 10.1002/mnfr.201900029. Epub 2019 Jul 16. PMID: 31295384. 77: Mansour DF, Abdallah HMI, Ibrahim BMM, Hegazy RR, Esmail RSE, Abdel-Salam LO. The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract. Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2551-2561. doi: 10.31557/APJCP.2019.20.8.2551. PMID: 31450931; PMCID: PMC6852799. 78: Herve T, Raphaël KJ, Ferdinand N, Victor Herman N, Willy Marvel NM, Cyril D'Alex T, Laurine Vitrice FT. Effects of Ginger (Zingiber officinale, Roscoe) Essential Oil on Growth and Laying Performances, Serum Metabolites, and Egg Yolk Antioxidant and Cholesterol Status in Laying Japanese Quail. J Vet Med. 2019 Mar 13;2019:7857504. doi: 10.1155/2019/7857504. PMID: 31001562; PMCID: PMC6436365. 79: Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, Wu YC, Hsieh TJ, Chang FR. 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. Int J Mol Sci. 2017 Jan 17;18(1):168. doi: 10.3390/ijms18010168. PMID: 28106738; PMCID: PMC5297801. 80: Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Mir Taheri M. The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients. Iran J Pharm Res. 2015 Winter;14(1):131-40. PMID: 25561919; PMCID: PMC4277626. 81: Alshibani N, Al-Kattan R, Alssum L, Basudan A, Shaheen M, Alqutub MN, Al Dahash F. Postoperative Analgesic and Anti-inflammatory Effectiveness of Ginger (Zingiber officinale) and NSAIDs as Adjuncts to Nonsurgical Periodontal Therapy for the Management of Periodontitis. Oral Health Prev Dent. 2022 Jun 13;20(1):227-232. doi: 10.3290/j.ohpd.b3125633. PMID: 35695692. 82: Rayati F, Hajmanouchehri F, Najafi E. Comparison of anti-inflammatory and analgesic effects of Ginger powder and Ibuprofen in postsurgical pain model: A randomized, double-blind, case-control clinical trial. Dent Res J (Isfahan). 2017 Jan-Feb;14(1):1-7. doi: 10.4103/1735-3327.201135. PMID: 28348610; PMCID: PMC5356382. 83: M I, C O E, P N O, N N. Effect of Unripe Plantain (Musa paradisiaca) and Ginger (Zingiber officinale) on Blood Glucose, Body Weight and Feed Intake of Streptozotocin-induced Diabetic Rats. Open Biochem J. 2015 Jan 30;9:1-6. doi: 10.2174/1874091X01509010001. PMID: 25674161; PMCID: PMC4319205. 84: Pagano E, Souto EB, Durazzo A, Sharifi-Rad J, Lucarini M, Souto SB, Salehi B, Zam W, Montanaro V, Lucariello G, Izzo AA, Santini A, Romano B. Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects. Phytother Res. 2020 Dec 5. doi: 10.1002/ptr.6964. Epub ahead of print. PMID: 33278054. 85: Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med. 2012 Jul 10;12:92. doi: 10.1186/1472-6882-12-92. PMID: 22781186; PMCID: PMC3518208. 86: Darvishzadeh-Mahani F, Esmaeili-Mahani S, Komeili G, Sheibani V, Zare L. Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats. J Ethnopharmacol. 2012 Jun 14;141(3):901-7. doi: 10.1016/j.jep.2012.03.030. Epub 2012 Mar 26. PMID: 22472107. 87: Matsuda A, Wang Z, Takahashi S, Tokuda T, Miura N, Hasegawa J. Upregulation of mRNA of retinoid binding protein and fatty acid binding protein by cholesterol enriched-diet and effect of ginger on lipid metabolism. Life Sci. 2009 Jun 19;84(25-26):903-7. doi: 10.1016/j.lfs.2009.04.004. Epub 2009 Apr 18. PMID: 19379761. 88: Azzeh FS. Synergistic effect of green tea, cinnamon and ginger combination on enhancing postprandial blood glucose. Pak J Biol Sci. 2013 Jan 15;16(2):74-9. doi: 10.3923/pjbs.2013.74.79. PMID: 24199490. 89: Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr. 2000 May;130(5):1124-31. doi: 10.1093/jn/130.5.1124. PMID: 10801908. 90: Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 1997 May;56(5):379-84. doi: 10.1016/s0952-3278(97)90587-1. PMID: 9175175. 91: Al-Khalaifah H, Al-Nasser A, Al-Surrayai T, Sultan H, Al-Attal D, Al-Kandari R, Al-Saleem H, Al-Holi A, Dashti F. Effect of Ginger Powder on Production Performance, Antioxidant Status, Hematological Parameters, Digestibility, and Plasma Cholesterol Content in Broiler Chickens. Animals (Basel). 2022 Mar 31;12(7):901. doi: 10.3390/ani12070901. PMID: 35405889; PMCID: PMC8996832. 92: Akinyemi AJ, Ademiluyi AO, Oboh G. Inhibition of angiotensin-1-converting enzyme activity by two varieties of ginger (Zingiber officinale) in rats fed a high cholesterol diet. J Med Food. 2014 Mar;17(3):317-23. doi: 10.1089/jmf.2012.0264. Epub 2014 Jan 16. PMID: 24433069. 93: Bhandari U, Sharma JN, Zafar R. The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol fed rabbits. J Ethnopharmacol. 1998 Jun;61(2):167-71. doi: 10.1016/s0378-8741(98)00026-9. PMID: 9683348. 94: Ghayur MN, Khan AH, Gilani AH. Ginger facilitates cholinergic activity possibly due to blockade of muscarinic autoreceptors in rat stomach fundus. Pak J Pharm Sci. 2007 Jul;20(3):231-5. PMID: 17545109.